The predicted clearances in LM, with and without NADPH and hepatocytes for human, rat, mouse, dog, and monkey
The human clearance is predicted to be high under all conditions. For the preclinical species, the clearance is predicted to be low in LM without NADPH. The in vivo clearance is low in rats, moderate in mice and dogs, and high in monkeys.
| Predicted CLhep | |||||
|---|---|---|---|---|---|
| Human | Rat | Mouse | Dog | Monkey | |
| ml · min−1 · kg−1 | |||||
| Liver microsomes | |||||
| with NADPH | 19 | 39 | 79 | 28 | 36 |
| without NADPH | 18 | 7.8 | 25 | 6.8 | 2.4 |
| Hepatocytes | 19 | 25 | 63 | 19 | 32 |
| In vivo CL | 4.7 | 43 | 14 | 33 | |