TABLE 3
Summary of carfilzomib metabolites identified in rat plasma, urine, and bile samples
| Metabolite Code | Proposed Structure | Molecular Mass | Retention Time | Source |
|---|---|---|---|---|
| Da | min | |||
| M1* |  | 131 | 10.4 | RP, RU, and RB |
| M2* |  | 201 | 13.1 | RP, RU, and RB |
| M5* |  | 181 | 13.1 | RP, RU, and RB |
| M7* |  | 165 | 15.9 | RP and RU |
| M8* |  | 189 | 17.2 | RP, RU, and RB |
| M9* |  | 310 | 16.7 | RP and RB |
| M10 |  | 195 | 19.0 | RU |
| M11* |  | 318 | 20.2 | RP, RU, and RB |
| M12* |  | 294 | 21.2 | RP, RU, and RB |
| M13* |  | 278 | 25.1 | RB |
| Da | min | |||
| M14* |  | 306 | 25.9 | RP, RU, and RB |
| M15* |  | 419 | 33.0 | RP, RU, and RB |
| M16* |  | 737 | 43.8 | RP, RU, and RB |
| M17 |  | 735 | 51.1 | RP and RU |
| M18 |  | 735 | 51.1 | RU and RB |
| M19 |  | 717 | 59.3 | RB |
| M20 |  | 733 | 46.2 | RU and RB |
| Da | min | |||
| M21 |  | 733 | 50.1 | RU and RB |
| M22 |  | 749 | 42.5 | RB |
| M23 |  | 753 | 39.1 | RB |
| M24 |  | 735 | 44.4 | RU |
RP, rat plasma; RU, rat urine; RB, rat bile.
* These metabolites were also observed in monkey plasma samples obtained in a 9-month toxicity study.