TABLE 4

Predicted human V_ss (l/kg) by allometric scaling of V_ss or V_ss,u and the corresponding allometric constants

Drug	Allometry of V_ss				Allometry of V_ss,u				Observed Human^{^a}
Drug	Predicted V_ss	a	b	R²	Predicted V_ss	a	b	R²	Observed Human^{^a}
Cefotetan	0.19	0.23	0.96	0.99	0.16	0.76	1.1	0.92	0.13
Tiludronate	1.9	9.4	0.62	0.94	0.81	35	0.66	0.86	1.0
Captopril	4.1	2.2	1.1	0.99	5.8	3.5	1.2	0.94	0.81
Cefazolin	0.18	0.21	0.97	0.96	0.067	1.6	0.82	0.88	0.11
Cefoperazone	0.13	0.28	0.83	0.93	0.13	1.5	1.1	0.83	0.14
Diclofenac	0.087	0.42	0.63	0.95	0.052	56	0.65	0.95	0.17
Fluvastatin	1.7	1.3	1.1	0.85	6.7	134	1.5	0.96	0.42
Furosemide	0.18	0.16	1.0	0.97	0.02	7.80	0.67	1.0	0.11
Gemfibrozil	1.0	0.33	1.3	0.84	1.6	42	1.5	0.84	1.1
Indomethacin	5.3	2.2	1.2	0.96	5.2	611	1.0	0.97	0.93
Ketoprofen	0.20	0.34	0.87	1.0	0.029	26	0.70	0.99	0.13
Naproxen	0.08	0.14	0.86	0.99	0.12	26	1.1	1.0	0.10
Troglitazone	0.61	0.88	0.92	1.0	1.4	122	1.2	1.0	0.71
Valproic acid	0.12	0.40	0.71	0.90	0.077	1.8	0.96	1.0	0.15
Warfarin	0.17	0.19	0.98	0.94	0.033	28	0.62	0.92	0.11
Phenytoin	5.3	1.3	1.3	0.84	3.6	7.2	1.3	0.83	1.4
Antipyrine	0.52	0.84	0.89	1.0	0.55	1.2	0.89	1.0	0.87
Caffeine	0.71	0.87	0.95	1.0	0.50	1.1	0.88	1.0	0.73
Coumarin	15	2.3	1.4	1.0	10	8.0	1.5	1.0	2.2
Flunisolide	4.5	3.3	1.1	1.0	4.0	14	1.0	1.0	1.8
Isosorbide dinitrate	1.5	3.5	0.80	0.95	0.87	5.6	0.70	0.97	1.9
Isosorbide mononitrate	0.51	0.80	0.90	0.98	0.25	1.4	0.67	0.97	0.60
Lorazepam	7.6	1.5	1.4	0.93	5.5	16	1.4	0.91	1.3
Zidovudine	1.1	1.2	0.99	1.0	0.99	1.6	0.97	1.0	1.8
Cyclophosphamide	0.97	0.88	1.0	0.97	1.4	1.2	1.1	0.98	0.70
Felodipine	2.5	7.3	0.75	0.80	5.4	989	0.57	0.38	9.7
Lamivudine	0.67	1.4	0.82	1.00	0.72	1.5	0.85	1.0	1.3
Midazolam	1.2	2.3	0.86	0.94	1.02	89	1.0	1.0	1.1
Mifepristone	40	8.3	1.4	0.94	11	440	1.2	0.98	1.5
Nifedipine	2.8	0.27	1.6	0.99	0.42	18	0.61	0.97	0.78
Indinavir	0.58	1.7	0.75	0.97	0.63	5.7	0.67	0.99	0.82
Amiodarone	0.82	23	0.21	0.77	0.90	413	0.26	0.63	66
Biperiden	3.8	9.3	0.79	0.88	7.1	95	0.85	0.94	6.2
Bupivacaine	0.33	0.93	0.76	1.0	0.85	5.1	1.0	0.93	0.84
Chlorpromazine	6.8	19.0	0.76	0.92	4.3	208	0.58	0.50	11
Cimetidine	1.3	2.6	0.84	1.00	1.2	3.5	0.81	1.0	1.2
Citalopram	6.2	15	0.79	1.00	6.5	41	0.84	0.99	14
Diltiazem	20	4.9	1.3	0.92	11	19	1.2	0.85	3.1
Erythromycin	0.59	4.2	0.54	0.69	0.61	10	0.59	0.86	0.89
Haloperidol	27	11	1.2	0.90	9.5	73	1.00	0.90	18
Hydrodolasetron	15	16	0.98	0.93	11	71	0.89	0.92	11
Imipramine	5.7	9.3	0.88	0.99	4.9	63	0.88	0.98	13
Lidocaine	1.1	1.9	0.87	0.94	0.75	4.8	0.84	0.94	1.1
Metoprolol	2.6	5.2	0.83	0.97	2.7	7.0	0.89	0.96	4.2
Propafenone	7.1	5.6	1.1	0.98	4.5	57	0.95	0.99	2.2
Propranolol	2.4	4.6	0.85	0.95	3.1	19	0.94	0.95	3.6
Venlafaxine	2.2	5.0	0.81	1.0	1.7	6.2	0.70	1.0	4.4
Verapamil	6.2	4.4	1.1	1.0	5.8	22	1.1	1.0	3.7
Disopyramide	1.1	3.9	0.70	0.98	0.93	6.8	0.72	1.0	0.78
Imatinib	17	4.8	1.3	1.0	8.8	106	0.96	0.99	3.9
Irinotecan	0.77	2.4	0.74	0.96	2.0	14	0.90	0.96	3.8
Nicardipine	1.7	1.4	1.0	0.99	0.97	75	0.88	0.99	0.64
Nicotine	1.5	3.3	0.82	0.92	1.5	3.3	0.82	0.92	2.6
Quinidine	0.96	3.2	0.72	0.58	3.2	26	0.92	0.82	3.0
Vinblastine	0.59	5.4	0.48	0.85	1.5	46	0.59	0.64	24
Cefpiramide	0.23	0.23	1.0	0.87	0.14	1.7	1.4	0.86	0.11
Ciprofloxacin	1.7	3.4	0.83	0.96	1.4	5.4	0.73	1.0	2.3
Doxorubicin	42	27	1.1	0.98	41	333	0.98	0.95	25
Gabapentin	0.10	0.82	0.51	0.76	0.10	0.82	0.51	0.76	0.82
Lamifiban	0.83	0.31	1.2	0.97	0.83	0.33	1.2	0.97	0.29
Levofloxacin	0.88	2.6	0.74	1.0	0.72	3.0	0.72	0.99	1.2
Methotrexate	1.1	0.55	1.2	0.96	0.82	1.5	1.2	0.97	0.67
Morphine	10	4.4	1.2	0.93	11	6.5	1.2	0.92	3.3
Naltrexone	14	4.7	1.3	0.99	15	8.1	1.3	0.96	7.6
Telmisartan	2.3	2.0	1.0	0.98	0.35	232	0.84	1.0	5.3
Topotecan	3.2	0.84	1.3	0.99	5.1	2.9	1.2	0.93	1.8
Verlukast	0.13	0.52	0.68	1.0	0.011	152	0.46	0.51	0.11

↵a See Table 2 for source of in vivo data.