Summary of DDI prediction accuracy using TDI kinetic parameters (Ki, kinact) generated from HLM method and HH methods
| DDI Prediction Accuracy | |||
|---|---|---|---|
| HLM | HH: Add Method | HH: Dilution Method | |
| Erythromycin (n = 11) | |||
| MRS | 7.73 | 0.317 | −0.01 |
| RMSE | 10.8 | 1.10 | 1.06 |
| GMFE | 2.75 | 1.27 | 1.28 |
| Verapamil (n = 7) | |||
| MRS | 1.62 | −0.49 | −0.15 |
| RMSE | 2.58 | 1.01 | 1.02 |
| GMFE | 1.50 | 1.31 | 1.28 |
| Diltiazem (n = 12) | |||
| MRS | 2.64 | −0.85 | −1.01 |
| RMSE | 4.15 | 1.07 | 1.22 |
| GMFE | 1.71 | 1.44 | 1.54 |
| All (n = 30) | |||
| MRS | 4.27 | −0.34 | −0.44 |
| RMSE | 7.17 | 1.07 | 1.11 |
| GMFE | 1.97 | 1.35 | 1.38 |