TABLE 5

Qualitative analysis of the accuracy of DDI predictions using various estimates of [I] in vivo

Assumptions of [I]SensitivitySpecificity
Cmax9146
Hep_in10025
Liver10017
Cmax + gut9117
Hep_in + gut10013
Liver + gut1008
fu.Cmax36100
fu.Hep_in82100
fu.Liver8696
fu.(Cmax + gut)8296
fu.(Hep_in + gut)9596
fu.(Liver + gut)9196
  • Sensitivity, true positives identified as a percentage of total positive DDIs (AUC ratio >1.2); Specificity, true negatives identified as a percentage of total negative DDIs (AUC ratio <1.2); Cmax, maximal systemic concentration; Hep_in, hepatic inlet (portal vein) concentration; Liver, estimated liver concentration; + gut, inclusion of intestinal CYP3A4 inhibition term (where appropriate); fu, fraction unbound in blood.