TABLE 1

Physicochemical and binding dataa for a series of 5-n-alkyl-5-ethyl barbituric acids

Barbituric Acid HomologMol. Wt.pKaLogPfuR
n-Pentyl226.28.002.200.51b1.56b
n-Hexyl240.27.743.080.191.00
n-Heptyl254.27.783.640.0610.98
n-Octyl268.27.783.850.0261.08
n-Nonyl282.27.824.130.00931.05
  • fu, fraction unbound in rat plasma; R, whole blood-to-plasma concentration ratio.

  • a Toon and Rowland, 1983.

  • b Values for i-pentyl derivative because equivalent values not available for n-pentyl derivative.