Structure | Substance | Average IC50a | Ratio: IC50(0)/IC50(30) | |
---|---|---|---|---|
IC50(0) | IC50(30) | |||
μM | ||||
Gemfibrozil | 72 ± 7.2 | 72 ± 6.2 | 1.0 | |
Gemfibrozil acyl-β-d-glucuronide | 13 ± 2.7 | 1.0 ± 0.06 | 13 | |
BTFM gemfibrozil | 13 ± 2.1 | 17 ± 2.5 | 0.7 | |
BTFM gemfibrozil acyl-β-d-glucuronide | 37 ± 3.2 | 43 ± 3.1 | <1.0 | |
o-Me gemfibrozil | >80 (15 ± 7)b | >80 (14 ± 7)b | 1.0 | |
o-Me gemfibrozil acyl-β-d-glucuronide | 55 ± 6 | 17 ± 0.3 | 3.2 | |
m-Me gemfibrozil | >80 (10 ± 6)b | >80 (9 ± 5)b | 1.0 | |
m-Me gemfibrozil acyl-β-d-glucuronide | >120 (29 ± 6)c | >120 (40 ± 3)c | >1.0 |