TABLE 6

Results of mRNA quantitation by quantitative real-time PCR

No. of CES Transcripts per 1000 Transcripts of β-Actin (±S.E.)
Cynomolgus Monkey 1Beagle Dog 1Beagle Dog 2
CES1CES2CES1CES2CES1CES2
StomachN.D.244 ± 79N.D.N.D.N.D.N.D.
Duodenum41.8 ± 4.3151 ± 26N.D.N.D.N.D.N.D.
Jejunum2.45 ± 0.35487 ± 168N.D.N.D.N.D.N.D.
Ileum4.71 ± 0.0394.7 ± 25.1N.D.N.D.N.D.N.D.
Colon0.0790 ± 0.031648.5 ± 28.6N.D.N.D.N.D.N.D.
Lung20.1 ± 2.912.8 ± 2.46.72 ± 2.37N.D.22.1 ± 6.3N.D.
Kidney95.2 ± 5.254.4 ± 7.237.5 ± 10.5N.D.0.813 ± 0.538N.D.
Liver841 ± 79878 ± 89103 ± 14N.D.398 ± 9N.D.
HeartN.A.N.A.N.D.N.D.N.A.N.A.
  • N.A., not available; N.D., not detected.