TABLE 1

Kinetic parameters for the uptake of various compounds in dog Oatp1b4-expressing HEK293 cells

	V_max	K_m^{^a}	V_max/K_m + P_dif	K_m^b		Reference
	V_max	K_m^{^a}	V_max/K_m + P_dif	OATP1B1	OATP1B3	OATP1B1	OATP1B3
	pmol · min⁻¹ · mg protein⁻¹	μM	μl · min⁻¹ · mg protein⁻¹	μM
BSP	319 ± 30	2.72 ± 0.31	117 ± 17	0.0364–0.3	0.4–3.3	Kullak-Ublick et al., 2001; Y. Debori, K. Maeda, and Y. Sugiyama, unpublished data	Cui et al., 2001; Kullak-Ublick et al., 2001
Pitavastatin	514 ± 56	5.49 ± 0.73	93.6 ± 16.1	3.00 ± 0.39	3.25 ± 0.44	Hirano et al., 2004	Hirano et al., 2004
E₁S	952 ± 188	39.0 ± 8.5	24.4 ± 7.2	0.068 ± 0.46		Tamai et al., 2001; Hirano et al., 2004
Glibenclamide	24.0 ± 7.3	0.619 ± 0.211	46.8 ± 17.7	0.680 ± 0.367	2.44 ± 0.82	Unpublished data	Unpublished data
Valsartan	348 ± 32	7.15 ± 0.78	52.8 ± 6.9	1.39 ± 0.24	18.2 ± 5.9	Yamashiro et al., 2006	Yamashiro et al., 2006
E₂G	106 ± 21	6.65 ± 1.36	18.2 ± 4.6	3.71–8.29	5.4–24.6	Tamai et al., 2001; Hirano et al., 2004	König et al., 2000; Hirano et al., 2004
Taurocholate	150 ± 66	13.9 ± 6.6	14.1 ± 7.0	10–33.8	5.8 ± 1.2	Hsiang et al., 1999; Cui et al., 2001	Abe et al., 2001
DHEAS	608 ± 147	14.5 ± 3.5	51.7 ± 14.4	21.5 ± 2.5	>30	Cui et al., 2001; Hsiang et al., 1999	Cui et al., 2001
Olmesartan	151 ± 27	7.82 ± 1.54	23.0 ± 5.1	12.8–42.6	44.2–71.8	Nakagomi-Hagihara et al., 2006; Yamada et al., 2007	Nakagomi-Hagihara et al., 2006; Yamada et al., 2007

↵a Data shown in Fig. 2 were used to determine these kinetic parameters calculated by nonlinear regression analysis as described under Materials and Methods. Each parameter represents the mean ± computer-calculated S.D.
b Values represent the mean ± computer-calculated S.D. or the range of K_m values of human OATP1B1 and OATP1B3 reported previously.