TABLE 1

Quantification of the expression and enzyme activity of UGT1A1 and UGT1A6 in human liver and kidney microsomes

Data are means ± S.D. for quantification in n tissue samples. Measurements were performed on between three and seven replicates.

TissueUGT1A1 ExpressionUGT1A1 ActivityUGT1A6 ExpressionUGT1A6 Activity
μg/g tissuenmol · min1 · g tissue1μg/g tissuenmol · min1 · g tissue1
Liver (n = 29)0.36 ± 0.264.07 ± 3.061.18 ± 1.074.89 ± 4.32
Range0.04–1.140.59–14.10.087–4.59BLQ-13.34
Kidney (n = 4)BLQBLQ0.44 ± 0.073.28 ± 0.31
Range0.35–0.512.82–3.45
  • BLQ, below limit of quantification.