TABLE 4

Correlation of enzyme activity to protein level or mRNA expression level of drug-metabolizing enzymes

Least-squares regression analysis was done for protein or mRNA expression levels (x-values) against enzyme activity (y-values). Enzyme activity of CYP2E1 and CYP4A11 was evaluated in terms of 11-hydroxylation and 12-hydroxylation of lauric acid, respectively. Data points and regression lines are shown in Fig. 3.