TABLE 6

Correlation between protein and mRNA expression levels of transporters

Least-squares regression analysis was done for protein expression levels (x-values, pmol/mg protein) against mRNA expression levels (y-values, relative amount to β-actin); each data point is shown in Fig. 5.

Transporter1/Sloper2
Canalicular localized
    MRP225.90.223
    MDR1131.10.185
    BSEP<0.100
    MATE1<0.100
    BCRP<0.100
Sinusoidal localized
    OATP1B159.30.727
    OATP2B1−21.20.380
    MRP1−2,4000.246
    OCT1<0.100
    NTCP<0.100
    OATP1B3<0.100
Localization unknown
    ABCA8<0.100

  • 1/Slope, the reciprocal number of slope of regression line; r2, correlation coefficient of regression line.