The observed and predicted AUCm/AUCp values for the dextrorphan/dextromethorphan, 5OH-omeprazole/omeprazole, and omeprazole sulfone/omeprazole metabolite/parent pairs
The in vitro system used to determine the formation and elimination clearances, the predicted AUCm/AUCp for each pair using eqs. 6 and 7, and the AUCm/AUCp predicted/observed ratio are listed.
| Parent | Metabolite | Observed AUCm/AUCp (Range) | In Vitro System | Equation Used | Predicted AUCm/AUCp | Predicted/Observed (Range) |
|---|---|---|---|---|---|---|
| Dextromethorphan | Dextrorphan | 0.61 (0.52–0.70) | Pooled HLM | 6 | 2.3 | 3.8 (3.3–4.4) |
| 7 | 1.3 | 2.1 (1.9–2.5) | ||||
| Omeprazole | 5OH-Omeprazole | 0.48 (0.24–0.74) | Hepatocytes | 6 | 0.37 | 0.78 (0.50–1.5) |
| 7 | 0.36 | 0.75 (0.49–1.5) | ||||
| Omeprazole | Omeprazole sulfone | 0.85 (0.79–0.94) | Pooled HLM | 6 | 2.8 | 3.3 (3.0–3.5) |
| 7 | 2.6 | 3.1 (2.8–3.3) | ||||
| Hepatocytes | 6 | 0.90 | 1.1 (0.96–1.2) | |||
| 7 | 0.90 | 1.1 (0.96–1.2) |