TABLE 2

Characteristics of control and CRF rats

Data are the mean ± S.D. Measurements were made at the time of sacrifice. Twenty-four-hour urinary collection was begun the day before. Blood urea and creatinine and urine creatinine were determined with an Architect C1600 clinical analyzer (Abbott Laboratories).

Control (n = 32)CRF (n = 32)p Value
Body weight (g)352.8 ± 29.5333.0 ± 54.50.07
Serum creatinine (μmol/l)55.4 ± 10.5205.0 ± 90.3<0.001
Creatinine clearance (μl/100 g b.wt./min)309.1 ± 82.470.1 ± 35.5<0.001
Serum urea (mmol/l)4.5 ± 1.038.4 ± 17.9<0.001