B/P partitioning in rats administered GHB (±) l-lactate
Using a Student's t test, no significant difference was determined between animals administered GHB at 1500 mg/kg compared to those administered GHB at 1500 mg/kg + l-lactate (P > 0.05). Data presented as mean (S.D.).
| Regimen | B/P Ratio |
|---|---|
| GHB 400-1500 mg/kg† | 0.75 |
| GHB 600 or 1500 mg/kg + l-lactate† | 0.76 |
| GHB 1500 mg/kg†† | 0.74 (0.07) |
| GHB 1500 mg/kg + l-lactate 66 mg/kg + 302.5 mg/kg per hour†† | 0.75 (0.07) |
↵† Ratio determined using data from all animals, including serial and sacrificial sampling studies (n = 74 rats total) and both l-lactate doses (330 mg/kg + 121 mg/kg per hour and 66 mg/kg + 302.5 mg/kg per hour). No S.D. was determined because sacrificial sampling did not allow determination of individual B/P ratios across a concentration range.
↵†† Mean of individual B/P ratios determined from serial sampling study only (n = 4–5 in each group). These values were used for statistical comparison.