TABLE 3

Experimental conditions and RI values in PXB mice used for PK study

Each compound was administered intravenously to PXB mice at 0.3 to 5 mg/kg body weight. The values of RI of PXB mice ranged from 73.4 to 93.4%. Each value represents the mean ± S.D. (n = 3–5).

CompoundsDoseRICLtt1/2
mg/kg%ml · min1 · kg1h
Dapsone3.077.4 ± 5.52.1 ± 0.54.5 ± 1.1
6-Deoxypenciclovir3.093.4 ± 4.271.2 ± 13.00.1 ± 0.1
Diclofenac3.076.4 ± 2.116.4 ± 4.30.6 ± 0.2
Fasudil3.075.8 ± 1.3198.1 ± 14.60.3 ± 0.1
Ibuprofen5.073.4 ± 3.23.8 ± 1.00.7 ± 0.1
Ketoprofen3.074.0 ± 1.13.3 ± 0.61.1 ± 0.1
Lamotrigine3.077.1 ± 4.01.4 ± 0.210.1 ± 0.9
Mirtazapine3.079.8 ± 1.730.4 ± 9.46.0 ± 1.4
(S)-Naproxen5.082.2 ± 6.12.2 ± 0.54.8 ± 2.7
Salbutamol3.074.5 ± 0.779.9 ± 34.00.6 ± 0.3
Sulindac3.074.5 ± 2.05.6 ± 1.31.2 ± 0.8
(S)-Warfarin0.375.3 ± 1.80.2 ± 0.18.2 ± 2.8
Zaleplon3.077.1 ± 3.748.1 ± 7.10.7 ± 0.4