TABLE 2

Estimation of CLint,in vitro (μl · min−1 · 106 cells−1) in PXB mice hepatocytes and scaling to humans and PXB mice

CLint,in vitro (μl · min−1 · 106 cells−1) values were converted to CLint,in vitro (ml · min−1 · kg−1) for the whole body. CLint,in vitro data were scaled up using physiological parameters, human liver weight (26 g/kg) and PXB mouse liver weight (140 g/kg), and the hepatocellularity (132 × 106 cells/g liver) of PXB mice. Each value represents the mean ± S.D. (n = 3).

CompoundsCLint,in vitroScaled CLint,in vitro (Human)Scaled CLint,in vitro (PXB Mice)
μl · min1 · 106 cells1ml · min1 · kg1
Dapsone2.3 ± 1.28.0 ± 4.043.1 ± 21.3
6-Deoxypenciclovir5.3 ± 1.218.3 ± 4.298.6 ± 22.4
Diclofenac24.7 ± 1.284.7 ± 4.0455.8 ± 21.3
Fasudil35.7 ± 13.3122.4 ± 45.6659.1 ± 245.4
Ibuprofen13.3 ± 2.145.8 ± 7.1246.4 ± 38.5
Ketoprofen6.0 ± 1.020.6 ± 3.4110.9 ± 18.5
Lamotrigine1.4 ± 1.04.8 ± 3.625.9 ± 19.2
Mirtazapine6.3 ± 1.221.7 ± 4.0117.0 ± 21.3
(S)-Naproxen12.7 ± 2.543.5 ± 8.6234.1 ± 46.5
Salbutamol1.0 ± 1.03.3 ± 3.317.9 ± 17.8
Sulindac2.0 ± 2.07.0 ± 6.737.6 ± 36.0
(S)-Warfarin1.2 ± 0.74.1 ± 2.522.2 ± 13.3
Zaleplon2.3 ± 1.28.0 ± 4.043.1 ± 21.3