TABLE 1

Pharmacokinetic parameters of phenacetin and acetaminophen after intravenous dosing of phenacetin at 15 mg/kg^a

	Phenacetin					Acetaminophen		AUC Metabolite/Parent
	AUC_last	t_1/2	MRT	V_ss	CL	C_max	AUC_last	AUC Metabolite/Parent
	nM · h	h	h	liter	ml · min⁻¹ · kg⁻¹	nM	nM · h
CC (wild-type)
Mean	3290	0.8	0.7	11	264	621	1162	0.34
S.D.	1462	0.3	0.2	3	110	386	693	0.07
CT (heterozygous)
Mean	4235	0.4	0.7	15	344	1231	2797	0.59
S.D.	1083	0.003	0.03	4	91	778	2236	0.35
TT (CYP1A2-deficient)
Mean	4823	0.5	0.8	15	292	246	601	0.13
S.D.	662	0.09	0.03	2	42	171	433	0.17

MRT, mean resonance time; V_ss, volume at steady state; CL, clearance.
↵a No significant difference found between groups.