TABLE 4

CLint,in vivo of humans and PXB mice, calculated by a well stirred model

CLint,in vivo was calculated from in vivo CLt, fu, Rb, and Q based on a well stirred model. The Q values of humans and PXB mice were set at 21 and 90 ml · min−1 · kg−1 (same as in normal mice), respectively. In addition, Rb and fu of human were assumed to be equivalent to those of PXB mice. If total CL of drugs exceeded liver blood flow, then the hepatic clearance was taken as 90% of liver blood flow. CLint,in vivo of 6-deoxypenciclovir, lamotrigine, and sulindac were evaluated from CLoral as CLoral/fu/Rb.

CompoundsHuman CLint,in vivoPXB Mice CLint,in vivo
ml · min1 · kg1
Dapsone2.08.6
6-Deoxypenciclovir118.0209.0
Diclofenac1004.34905.1
Fasudil370.61588.2
Ibuprofen147.1686.0
Ketoprofen232.2442.0
Lamotrigine0.73.2
Mirtazapine123.6408.7
(S)-Naproxen10.1230.2
Salbutamol13.51148.2
Sulindac47.886.5
(S)-Warfarin3.713.4
Zaleplon173.6261.3