Predicted median pharmacokinetic parameters from a 21-day study of 60 mg of raloxifene q.d. dosed to steady state with a single 5-mg dose of midazolam dosed on day 14
| PK Profile: Midazolam CLoxidative Simcyp | Midazolam Interaction Study | |||
|---|---|---|---|---|
| Raloxifene CLHIM+HLM Simcyp | Raloxifene CLoxidative Simcyp | |||
| With UGT KI/kinact | Without UGT KI/kinact | |||
| Raloxifene | ||||
| Tmax, h | ||||
| Cmax, μg/l | 2.3 | 16.5 | 22 | |
| AUC0–24 h, μg · h−1 · l−1 | 48 | 339 | 462 | |
| Midazolam | ||||
| Tmax, h | 2.6 | 2.6 | 2.5 | 2.6 |
| Cmax, μg/l | 9 | 12 | 13 | 24 |
| AUC0–24 h, μg · h−1 · l−1 | 54 | 68 | 91 | 224 |
| CL/F, l/h | 92 | 73 | 55 | 22 |
| Cmax i/Cmax | 1.3 | 1.4 | 2.7 | |
| AUCi/AUC | 1.3 | 1.7 | 4.1 | |