TABLE 4

Scaled CL_{int, u, UGT} of seven drugs from human kidney, liver, and intestinal microsomal data obtained in the presence of 1 or 2% bovine serum albumin

Data represent the mean (±S.D.) of n = 3 for human kidney and liver microsomes or n = 1 for human intestine microsomes. Experiments were performed in duplicate.

Drug^{^a}	Primary UGT^{^b}	CL_{int, u, UGT}			Ratio of CL_{int, u, UGT}
Drug^{^a}	Primary UGT^{^b}	HLM	HKM	HIM	Kidney/Liver	Intestine/Liver	Kidney/Intestine
		ml · min⁻¹ · g tissue⁻¹			scaled per g tissue
Diclofenac	1A9/2B7	47.4 (7.8)	6.95 (1.15)	6.70	0.147	0.141	1.04
Ezetimibe	1A1	207 (23)	6.34 (1.34)	23.8	0.031	0.115	0.266
Gemfibrozil	2B7	73.6 (12.5)	24.4 (6.2)	0.824	0.332	0.011	29.7
Mycophenolic Acid	1A9	9.32 (1.77)	17.6 (2.4)	1.19	1.89	0.128	14.8
Naloxone	1A8/2B7	2.22 (0.17)	0.675 (0.082)	0.292	0.304	0.131	2.31
Propofol	1A9	8.05 (0.46)	13.1 (1.66)	2.13	1.63	0.264	6.16
Telmisartan	1A3	15.8 (2.3)	0.439 (0.222)	1.88	0.028	0.119	0.233

↵a One percent BSA used for diclofenac, gemfibrozil, mycophenolic acid, and telmisartan, and 2% BSA used for ezetimibe, naloxone, and propofol.
↵b References are listed elsewhere (Supplemental Table 10).