TABLE 1

Kinetic parameters, K_m and V_max, for lorcaserin N-carbamoyl glucuronide formation by human liver microsomes and recombinant UGT enzymes

UGT Enzymes Source	Kinetic Parameters
UGT Enzymes Source	K_m ± S.E.	V_max ± S.E.	CL_int	r²
	μM	pmol/mg protein/min	μl/mg protein/min
Human liver microsomes	128.1 ± 5.6	2379.2 ± 28.5	18.57	1.0
UGT1A9	518.0 ± 63.8	103.3 ± 5.1	0.199	0.97
UGT2B7	93.8 ± 8.6	186.4 ± 4.4	1.987	0.98
UGT2B15	51.6 ± 1.9	237.4 ± 2.8	4.601	1.0
UGT2B17	254.1 ± 13.3	155.3 ± 2.8	0.611	1.0