TABLE 2

Correlation coefficients (r²) of lorcaserin metabolite formation versus P450 marker activity in 16 individual human liver microsomes at a lorcaserin concentration of 10.0 μM

P450	Marker Reaction	r²
P450	Marker Reaction	N-Hydroxylorcaserin	7-Hydroxylorcaserin	5-Hydroxylorcaserin	1-Hydroxylorcaserin
1A2	Phenacetin O-deethylation	0.007	0.000	0.531	0.122
2A6	Coumarin 7-hydroxylation	0.047	0.020	0.011	0.000
2B6	(S)-Mephenytoin N-demethylation	0.674	0.062	0.003	0.088
2C8	Paclitaxel 6α-hydroxylation	0.016	0.000	0.084	0.001
2C9	Tolbutamide 4′-hydroxylation	0.004	0.154	0.040	0.023
2C19	(S)-Mephenytoin 4′-hydroxylation	0.000	0.001	0.014	0.003
2D6	Bufuralol 1′-hydroxylation	0.002	0.819	0.000	0.000
3A4	Testosterone 6β-hydroxylation	0.178	0.000	0.481	0.680^{^a}
4A11	Lauric acid 12-hydroxylation	0.055	0.002	0.000	0.000

↵a Only 3 of 16 individual HLM formed 1-hydroxylorcasrin.