TABLE 4

Kinetic parameters of 4′-hydroxyflurbiprofen formation with tienilic acid-created CYP2C9 equivalent genotypes

Data were fit to the Michaelis-Menten equation and are expressed as mean ± S.E. of the fit.

Chemical Genotype EquivalentVmaxKmVmax/Km
pmol · min−1 · mg protein−1μM
CYP2C9*1/*1858 ± 137 ± 1123
CYP2C9*1/*3490 ± 6**7 ± 0.470
CYP2C9*3/*3232 ± 5***17 ± 214

  • ↵** p < 0.01.

  • ↵*** p < 0.001.