Digoxin AUC changes in wild-type mice predosed intravenously with vehicles or inhibitors
Digoxin blood, brain, and CSF AUC in wild-type mice in the absence and presence of the inhibitors were determined, and AUC ratios were calculated.
| AUC Ratio | Ko143 | PSC833 | GF120918 |
|---|---|---|---|
| AUCblood, I/C | 0.85 | 1.95 | 1.82 |
| AUCbrain, I/C | 0.82 | 4.65 | 9.76 |
| AUCCSF, I/C | 1.48 | 5.07 | 6.56 |
| AUCbrain/blood, I/C | 0.96 | 2.39 | 5.35 |
| AUCCSF/blood, I/C | 1.73 | 2.60 | 3.60 |
| AUCCSF/brain, I/C | 1.80 | 1.09 | 0.67 |
I, inhibitor; C, control.