Formation of lorcaserin N-carbamoyl glucuronide in human liver, kidney, intestine, and lung (smoker and nonsmoker) microsomes in the presence of 100 μM lorcaserin (substrate)
| Experimental Tissue | Lorcaserin N-Carbamoyl Glucuronide ± S.E. | Foldless Compared with Liver Microsomes |
|---|---|---|
| pmol/mg protein/min | ||
| Liver | 1028.0 ± 21.6 | |
| Kidney | 185.9 ± 5.2 | 6-fold |
| Intestine | 133.1 ± 0.3 | 8-fold |
| Lung | ||
| Smoker | 1.116 ± 0.060 | 921-fold |
| Nonsmoker | 0.493 ± 0.070 | 2084-fold |