TABLE 3

Scaled CLint, u, UGT of seven drugs from human kidney, liver, and intestinal microsomal data obtained in the absence of albumin

Data represent the mean (±S.D.) of n = 3 for human kidney and liver microsomes or n = 1 for human intestine microsomes. Experiments were performed in duplicate.

DrugPrimary UGTaCLint, u, UGTRatio of CLint, u, UGT
HLMHKMHIMKidney/LiverIntestine/LiverKidney/Intestine
ml · min1 · g tissue1scaled per g tissue
Diclofenac1A9/2B730.5 (4.2)2.27 (0.73)1.540.0750.0511.47
Ezetimibe1A1117 (18)3.78 (0.78)8.610.0320.0730.439
Gemfibrozil2B710.4 (1.1)3.39 (0.07)0.4920.3280.0486.89
Mycophenolic acid1A93.13 (0.18)3.75 (0.74)0.2441.200.07815.4
Naloxone1A8/2B70.402 (0.049)0.140 (0.003)0.0100.3480.02613.5
Propofol1A92.71 (0.18)1.17 (0.41)1.290.4320.4750.908
Telmisartan1A33.08 (0.17)0.124 (0.020)0.4380.0400.1420.284
  • a References are listed elsewhere (Supplemental Table 10).