Model-estimated rat pharmacokinetic parameters of atomoxetine and duloxetine
Atomoxetine data are from Kielbasa et al. (2009).
| Parameter | Atomoxetine | Duloxetine | ||
|---|---|---|---|---|
| Estimate (% SEE) | Variability (% SEE) | Estimate (% SEE) | Variability (% SEE) | |
| CLu, l/h | 14.5 (8.69) | 38.6 (23.7) | 35.6 (17.6) | 64.6 (35.5) |
| Vu, liters | 6.92 (30.8) | 65.4 (80.1) | 33.2 (15.7) | 55.7 (46.3) |
| QBCB, l/h | 0.0000909 (29.9) | 0.0000527 (31.7) | ||
| QBBB, l/h | 0.00110 (34.5) | 0.000160 (15.8) | 55.4 (39.9) | |
| CLECF-CSF, l/h | 0.000129 (20.2) | 0.000024 (fixed) | ||
| CLECF-BC, l/h | 0.00216 (25.1) | 0.00168 (41.8) | ||
| CLBC-ECF, l/h | 0.000934 (25.7) | 0.00249 (50.6) | 60.6 (42.8) | |
| VBC, liters | 0.000990 (fixed) | 0.000990 (fixed) | ||
| VCSF, liters | 0.000250 (fixed) | 0.000250 (fixed) | ||
| VECF, liters | 0.000290 (fixed) | 0.000290 (fixed) | ||
| σprop | 34.7 (9.09) | 28.8 (14.6) | ||
% SEE, percentage S.E. of the estimate; σprop, proportional residual error.