Ratio of Kp in P-gp, Bcrp, and P-gp/Bcrp knockout mice versus Kp in wild-type mice
| Compound | P-gp | Bcrp | Pgp/Bcrp |
|---|---|---|---|
| KO/WT | KO/WT | KO/WT | |
| Amprenavir | 6.8 | 0.41 | 7.0 |
| Citalopram | 1.5 | 0.38 | 1.3 |
| Digoxin | 6.2 | 0.43 | 6.1 |
| Elacridar | 2.4 | 0.65 | 9.5 |
| Imatinib | 1.6 | 0.44 | 8.2 |
| Ko143 | N.A. | N.A. | N.A. |
| Loperamide | 14 | N.A. | 9.3 |
| Prazosin | 0.82 | 0.65 | 2.6 |
| Quinidine | 21 | 0.50 | 20 |
| Sulfasalazine | N.A. | N.A. | N.A. |
| Verapamil | 18 | 0.54 | 17 |
N.A., not available.