Percentage of inhibition of terfenadine hydroxylation (terfenadine) and astemizole O-demethylation (astemizole)
Values are average of duplicates.
| Drug | % Activity Remaining Terfenadine (Astemizole) | Drug | % Activity Remaining Terfenadine (Astemizole) |
|---|---|---|---|
| Lansoprazole | 0.7 (71.1) | Albendazole | 29.3 (65.5) |
| Orphenadrine | 1.2 (102.2) | Quercetin | 29.8 (44.7) |
| Verapamil | 1.3 (69.1) | Paroxetine HCl | 31.6 (39.0) |
| Danazol | 1.6 (8.0) | Mevinolin | 37.7 (13.6) |
| Cisapride | 3.2 | Amiodarone | 39.0 (18.7) |
| Miconazole | 3.4 (10.1) | Methadone | 43.0 (123.4) |
| Ketoconazole | 5.8 (5.4) | Domperidone | 43.5 (50.5) |
| Astemizole | 8.3 | Clomiphene | 44.2 (108.8) |
| Nicardipine | 8.9 (5.8) | Fluoxetine | 44.3 (87.0) |
| Loratadine | 11.4 (4.0) | Ranolazine | 45.1 (204.1) |
| Tamoxifen | 11.5 (9.1) | Nortriptyline | 45.3 (70.1) |
| Clotrimazole | 14.1 (5.6) | Methadone | 45.7 (123) |
| Simvastatin | 14.3 (5.0) | Omeprazole | 46.1 (70.5) |
| Haloperidol | 15.6 (14.7) | Fluvoxamine | 48.7 (54.4) |
| Mefloquine | 22.4 (44.6) | Cyclobenzaprine | 48.9 (65.9) |
| Amodiaquine | 22.5 (7.7) | Budesonide | 50.8 |
| Isradipine | 23.7 (13.6) | Clozapine | 51.3 (25.6) |
| Ivermectin | 26.2 (20.9) | Quinapril | 51.4 (64.1) |
| Pimozide | 27.29 (6.6) | Thioridazine | 51.7 (12.9) |