TABLE 2

Pharmacokinetic parameters of atomoxetine and duloxetine used in translational models to predict human brain extracellular pharmacokinetics

Duloxetine data are from Lobo et al. (2009).

ParameterAtomoxetineDuloxetine
ClinicalScaled from RatClinicalScaled from Rat
ka, h−13.10.168
CL/F, l/h20.645.1
V/F, liters121814
VCSF, liters0.160.16
VECF, liters0.310.31
VBC, liters1.041.04
CLPL-CSF, l/h0.00825NE
CLCSF-PL, l/h0.0205NE
QBCB, l/hNE0.0150.009
QBBB, l/h0.1810.026
CLECF-CSF, l/h0.0210.004
CLECF-BC, l/h0.3550.279
CLBC-ECF, l/h0.1530.412
ω-CL/F, %90.858.9
ω-V/F, %65.696.6
  • ω, intersubject variability; NE, not estimated.