Molecular Names | Protein Expression Level | |||
---|---|---|---|---|
Wild Type | Mdr1a/b(−/−) | Bcrp1(−/−) | Mdr1a/b(−/−)Bcrp1(−/−) | |
fmol/μg protein | ||||
ABC transporters | ||||
Abca1 | 0.397 ± 0.065 | 0.499 ± 0.041 | 0.358 ± 0.027 | 0.392 ± 0.056 |
Abca2 | N.D. | N.D. | N.D. | N.D. |
Mdr1a (Abcb1a) | 16.3 ± 0.8 | N.D. | 17.0 ± 0.3 | N.D. |
Mdr1b (Abcb1b) | N.D. | N.D. | N.D. | N.D. |
Mrp1 (Abcc1) | N.D. | N.D. | N.D. | N.D. |
Mrp2 (Abcc2) | N.D. | N.D. | N.D. | N.D. |
Mrp3 (Abcc3) | N.D. | N.D. | N.D. | N.D. |
Mrp4 (Abcc4) | 2.18 ± 0.13 | 2.31 ± 0.15 | 1.79 ± 0.09 | 1.98 ± 0.10 |
Mrp5 (Abcc5) | N.D. | N.D. | N.D. | N.D. |
Mrp6 (Abcc6) | N.D. | N.D. | N.D. | N.D. |
Bcrp (Abcg2) | 3.53 ± 0.21 | 4.20 ± 0.18 | N.D. | N.D. |
Mrp7 (Abcc7) | N.D. | N.D. | N.D. | N.D. |
SLC transporters | ||||
Glut1 (Slc2a1) | 110 ± 5 | 121 ± 6 | 115 ± 6 | 114 ± 5 |
Lat1 (Slc7a5) | 1.80 ± 0.32 | 2.03 ± 0.42 | 1.89 ± 0.41 | 1.71 ± 0.45 |
4F2 hc (Slc3a2) | 17.1 ± 1.0 | 20.5 ± 0.9 | 17.6 ± 0.7 | 18.6 ± 0.6 |
Mct1 (Slc16a1) | 25.2 ± 2.5 | 27.8 ± 1.9 | 27.5 ± 1.8 | 23.5 ± 0.7 |
Oatp2 (Slco1a1) | 1.55 ± 0.31 | 2.01 ± 0.12 | 1.92 ± 0.45 | 0.648 ± 0.155 |
Oatp14 (Slco161) | 1.70 ± 0.1 | 1.84 ± 0.09 | 1.68 ± 0.08 | 1.57 ± 0.17 |
Oat3 (Slc22a8) | 1.74 ± 0.18 | 1.75 ± 0.08 | 1.75 ± 0.27 | 1.47 ± 0.29 |
Ent1 (Slc29a1) | 1.18 ± 0.40 | 0.887 ± 0.151 | 1.15 ± 0.33 | 1.06 ± 0.30 |
Pmat | N.D. | N.D. | N.D. | N.D. |
Rlip76 | N.D. | N.D. | N.D. | N.D. |
Receptors | ||||
Insr | 0.797 ± 0.096 | 0.911 ± 0.039a | 0.837 ± 0.083a | 0.482 ± 0.019 |
Lrp1 | 1.02 ± 0.20a | 0.883 ± 0.008 | 1.01 ± 0.06a | 0.400 ± 0.001 |
Tfr1 | 5.16 ± 0.44 | 5.49 ± 0.42 | 4.91 ± 0.34 | 3.98 ± 0.40 |
Claudin-5 | 8.05 ± 1.73 | 9.16 ± 1.21 | 8.96 ± 1.15 | 6.40 ± 1.70 |
Cd147 | 21.3 ± 0.80 | 22.9 ± 0.80 | 23.3 ± 1.40 | 18.4 ± 1.60 |
Housekeeping genes | ||||
Na+/K+ ATPase | 39.1 ± 1.4 | 41.0 ± 1.2 | 41.8 ± 1.2 | 44.5 ± 1.8 |
γ-gtp | 3.25 ± 0.30 | 3.34 ± 0.38 | 3.10 ± 0.26 | 3.16 ± 0.24 |
N.D., not detected.
↵a Among the receptors that were studied, Insr and Lrp1 expression was trended lower in the P-gp/Bcrp combined knockout mice (p < 0.05 compared with P-gp/Bcrp combined knockout mice).