Cytochrome P450 inhibition by hydralazine in human liver microsomes
The following probe substrates were used: 10 μM phenacetin for CYP1A2, 5 μM paclitaxel for CYP2C8, 5 μM diclofenac for CYP2C9, 40 μM S-mephenytoin for CYP2C19, 5 μM dextromethorphan for CYP2D6, and 2 μM midazolam for CYP3A.
| Hydralazine | % Control Activity | |||||
|---|---|---|---|---|---|---|
| CYP1A2 | CYP2C8 | CYP2C9 | CYP2C19 | CYP2D6 | CYP3A | |
| 25 μM | 100 | 108 | 105 | 103 | 92 | 98 |
| 50 μM | 89 | 95 | 95 | 90 | 77 | 76 |