TABLE 6

Inhibitory effect of oseltamivir on [³H]GlySar uptake in P. pastoris cells expressing different mammalian species of Pept1 gene

Parameter estimates were expressed as means ± S.E. (n = 6). The data were fitted to eq. 2 using a weighting factor of 1/Y. GlySar was studied at 5.0 μM, whereas oseltamivir concentrations ranged from 0.5 to 200 mM. GlySar uptakes in vector alone were reduced by 10% or less over the oseltamivir concentrations studied.