TABLE 5

Effect of potential inhibitors on [³H]GlySar uptake in P. pastoris cells expressing different mammalian species of Pept1 gene

Data are expressed as means ± S.E. (n = 3). The results were vector-subtracted and are shown as a percentage of control (buffer).

Inhibitory Compound	Yeast Transformant
Inhibitory Compound	pPIC3.5K-hPept1	pPIC3.5K-mPept1	pPIC3.5K-rPept1
Control	100 ± 28	100 ± 7	100 ± 10
Glycine	130 ± 17	104 ± 6	91.5 ± 6.4
l-Histidine	122 ± 13	103 ± 6	113 ± 8
GlyPro	3.9 ± 1.7^*	1.9 ± 1.0^*	0.6 ± 0.3^*
Cefadroxil	6.4 ± 13.7^*	16.7 ± 1.7^*	23.1 ± 1.2^*
Cephradine	23.2 ± 5.4^*	9.8 ± 0.7^*	23.4 ± 1.8^*
Cefazolin	81.1 ± 2.6	87.4 ± 0.7	93.7 ± 6.3
Cephalothin	84.8 ± 3.3	85.0 ± 4.6	119 ± 1
Cephapirin	100 ± 14	83.7 ± 6.3	122 ± 5
Acyclovir	114 ± 8	99.8 ± 5.6	109 ± 10
Valacyclovir	3.5 ± 3.3^*	4.5 ± 1.1^*	5.5 ± 0.5^*
SITS	127 ± 12	86.1 ± 3.6	107 ± 10
TEA	113 ± 9	83.7 ± 2.0	94.8 ± 5.4
Elacridar	100 ± 6	89.3 ± 3.6	119 ± 3

↵* p ≤ 0.001 compared with control. GlySar was studied at 5.0 μM and the potential inhibitors at 10 mM.