TABLE 1

Hepatic uptake and metabolism characteristics of eight drugs

Values are taken from Yabe et al., 2011.

Compound	CL_active	P_diff	Kp_u^{^a}	fu_cell^{^a}	Metabolism
	μl · min⁻¹ · 10⁶ cells⁻¹
Atorvastatin	1500	5.35	494	0.056	Extensive
Clarithromycin	50.7	10.9	6.05	0.024	Moderate
Erythromycin	11.4	12.2	2.00	0.05	Moderate
Fexofenadine	167	6.75	25.5	0.10	Minor
Pitavastatin	197	18.8	22.9	0.028	Minor
Repaglinide	299	58.2	7.94	0.036	Extensive
Rosuvastatin	418	7.08	58.2	0.48	Minor
Saquinavir	239	191	2.34	0.0075	Extensive