TABLE 3

Modeling the depletion-time profiles for the conventional and media-loss methods at 0.1 μM initial substrate concentrations

CompoundCLmetCLuptakePdiffVcellVmedium
μl · min1 · 106 cells1μl/106 cellsμl
Atorvastatin77.4 ± 5.1393 ± 576234 ± 3032164 ± 370198 ± 29
Fexofenadine13.5 ± 2.2115 ± 13642.6 ± 23.6912 ± 384221 ± 25
Pitavastatin7.2 ± 3.7716 ± 255162 ± 21555 ± 185211 ± 29
Rosuvastatin3.1 ± 1.2627 ± 236190 ± 24192 ± 22186 ± 37