TABLE 1

Plasma and brain pharmacokinetic parameters calculated by noncompartmental analysis after administration of a single dose of elacridar in FVB wild-type mice

Routet1/2CmaxTmaxAUC0-lastAUC0-infKp
hμg/mlhμg · min/mlμg · min/ml
2.5 mg/kg i.v.
    Plasma4.40.564 ± 0.140.5138.6 ± 6.5161.40.82
    Brain1.51.05 ± 0.380.5128.3 ± 19.6131.3
100 mg/kg i.p.
    Plasma4.30.295 ± 0.060.563.5 ± 6.690.30.48
    Brain9.20.061 ± 0.02419.9 ± 4.743.5
100 mg/kg p.o.
    Plasma200.78 ± 0.128792.8 ± 67.914604.31
    Brain164.34 ± 0.7983887 ± 4106296