TABLE 4

Percentage of [14C] GDC-0980 free in mouse, rat, dog, monkey, and human plasma

Results reported as mean ± S.D. (n = 4).

SpeciesTotal GDC-0980 ConcentrationaFree [14C]GDC-0980
μM%
Mouse129 ± 3.1
1029 ± 2.6
4032 ± 1.2
Rat142 ± 3.5
1041 ± 2.9
4042 ± 0.94
Dog149 ± 1.8
1052 ± 2.4
4052 ± 1.1
Cynomolgus monkey146 ± 3.8
1048 ± 1.5
4051 ± 1.9
Human139 ± 2.8
1041 ± 0.29
4045 ± 2.6
  • a Unlabeled and 14C-labeled GDC-0980.