TABLE 3

Uptake kinetic parameters of rosuvastatin estimated in three human hepatocyte donors using a mechanistic two-compartment model

Uptake kinetics was measured in cryopreserved human hepatocytes plated for 6 h over 2 min at seven concentrations (0.1–300 μM).

DonorKm, uVmaxPdiff, ufumedCLactive, u
μMpmol · min1 · 106 cells1μl · min1 · 106 cells1μl · min1 · 106 cells1
HU412211.21040.3910.809.21
HU41999.8016.60.14811.69
HU808912.016.30.2430.961.35
Mean ± S.D.11.0 ± 1.145.5 ± 50.30.261 ± 0.1230.93 ± 0.134.09 ± 4.44