TABLE 8

Pharmacodynamic parameters estimated from MCF7-neo/HER2 tumor xenograft studies

ParameterEstimateCoefficient of Variation
%
kng, h−10.00422.7
Kmax, h−10.02011
KC50, μM2.025
n1 (fixed)
ED60, mg/kg1.1
Cstasis, μM0.52