TABLE 3

Blood-to-plasma ratio of [14C] GDC-0980 in mouse, rat, dog, monkey, and human whole blood

Results reported as mean ± S.D. (n = 3).

SpeciesTotal GDC-0980 ConcentrationaBlood-Plasma Ratio of [14C]GDC-0980
μM
Mouse10.75 ± 0.016
100.78 ± 0.049
400.85 ± 0.041
Rat10.97 ± 0.017
100.92 ± 0.045
400.90 ± 0.027
Cynomolgus monkey11.1 ± 0.0043
101.1 ± 0.035
401.0 ± 0.0087
Dog10.94 ± 0.039
100.85 ± 0.013
400.83 ± 0.0042
Human11.3 ± 0.015
101.1 ± 0.081
401.1 ± 0.055
  • a Unlabeled and 14C-labeled GDC-0980.