TABLE 2

In vitro clearance of VU0409106 (CL_int and CL_HEP) in multiple species hepatic S9, cytosol, and hepatocytes as well as CL_p in Sprague-Dawley rat and cynomolgus monkey

In vitro clearance was calculated as described under Materials and Methods.

	Rat			Monkey			Human
	CL_int^a	CL_HEP^b	CL_p_c	CL_int	CL_HEP	CL_p	CL_int	CL_HEP
	ml · min⁻¹ · kg⁻¹
S9 minus NADPH	25	18		34	19		1.0	1.0
S9 + NADPH	54	30		37	20		15	8.6
Cytosol	16	13		N.A.	N.A.		3.7	3.2
Hepatocytes	96	40		194	36		6.9	5.1
In vivo			43			24

CL_int, intrinsic clearance; CL_HEP, predicted hepatic clearance; CL_p, plasma clearance; N.A., not available.