Sulfasalazine and sulfapyridine pharmacokinetic parameters in Wistar TR− rats
Data are means ± S.D. n = 3.
Parameter | Wild-Type Wistar Rat | TR− Wistar Rat |
---|---|---|
Sulfasalazine (5 mg/kg i.v.) | ||
AUCinf, ng · h/ml | 12,300 ± 1630 | 7730 ± 1130* |
CL, ml · min−1 · kg−1 | 6.8 ± 1.0 | 10.9 ± 1.5* |
VD, SS, ml/kg | 244 ± 30 | 839 ± 79* |
t1/2, h | 1.5 ± 0.5 | 4.0 ± 0.3* |
Sulfasalazine (5 mg/kg p.o.) | ||
AUCinf, ng · h/ml | 1810 ± 215 | 462 ± 19* |
Cmax, ng/ml | 490 ± 108 | 144 ± 21* |
Tmax, h | 0.5 ± 0.0 | 0.25 ± 0.00* |
t1/2, h | 2.1 ± 0.2 | 2.3 ± 0.3 |
F, % | 3.8 ± 0.9 | 1.5 ± 0.2* |
Sulfasalazine (20 mg/kg sulfasalazine p.o.) | ||
M/P | 16 ± 1 | 34 ± 3* |
AUCinf, ng-eq · h/ml | 29,403 ± 3963 | 15,437 ± 1080* |
Cmax, ng-eq/ml | 4315 ± 320 | 3244 ± 139* |
Tmax, h | 4.0 ± 0.0 | 4.0 ± 0.0 |
t1/2, h | 2.3 ± 0.2 | 1.7 ± 0.5 |
AUCinf, area under the curve extrapolated to infinity; CL, clearance; VD, SS, volume of distribution; t1/2, half-life; Cmax, maximum concentration; Tmax, time to maximum concentration; F, bioavailability; M/P, metabolite/parent ratio.
↵* p < 0.05.