TABLE 4

Sulfasalazine and sulfapyridine pharmacokinetic parameters in Wistar TR− rats

Data are means ± S.D. n = 3.

ParameterWild-Type Wistar RatTR− Wistar Rat
Sulfasalazine (5 mg/kg i.v.)
    AUCinf, ng · h/ml12,300 ± 16307730 ± 1130*
    CL, ml · min−1 · kg−16.8 ± 1.010.9 ± 1.5*
    VD, SS, ml/kg244 ± 30839 ± 79*
    t1/2, h1.5 ± 0.54.0 ± 0.3*
Sulfasalazine (5 mg/kg p.o.)
    AUCinf, ng · h/ml1810 ± 215462 ± 19*
    Cmax, ng/ml490 ± 108144 ± 21*
    Tmax, h0.5 ± 0.00.25 ± 0.00*
    t1/2, h2.1 ± 0.22.3 ± 0.3
    F, %3.8 ± 0.91.5 ± 0.2*
Sulfasalazine (20 mg/kg sulfasalazine p.o.)
    M/P16 ± 134 ± 3*
    AUCinf, ng-eq · h/ml29,403 ± 396315,437 ± 1080*
    Cmax, ng-eq/ml4315 ± 3203244 ± 139*
    Tmax, h4.0 ± 0.04.0 ± 0.0
    t1/2, h2.3 ± 0.21.7 ± 0.5

  • AUCinf, area under the curve extrapolated to infinity; CL, clearance; VD, SS, volume of distribution; t1/2, half-life; Cmax, maximum concentration; Tmax, time to maximum concentration; F, bioavailability; M/P, metabolite/parent ratio.

  • ↵* p < 0.05.