Stability in microsomal incubations
The half-lives of ketoconazole and SR-9186 were evaluated in microsomal incubations containing high levels of HLM protein and 1 mM NADPH in 100 mM phosphate buffer, pH 7.4.
| t1/2 for HLM Protein | ||
|---|---|---|
| 0.2 mg/ml | 1.0 mg/ml | |
| min | ||
| Ketoconazole (1 μM) | 130 | 68 |
| SR-9186 (2.5 μM) | 380 | 110 |