TABLE 6

Concentrations of radioactivity (microgram equivalents of GDC-0980 per gram of sample) in tissues of male rats after a single oral dose of [14C]GDC-0980 at 2 mg/kg

TissueTime after Compound Administration
1 h8 h24 h120 h
Blood (in heart)1.71BQLBQLBQL
Bile (in duct)77.37.236.34BQL
Kidney cortex8.730.3160.320BQL
Kidney medulla8.500.3600.382BQL
Liver23.92.171.950.183
Urinary bladder3.520.170BQLBQL
Brain (cerebrum)0.151BQLBQLBQL
Brain (cerebellum)BQLBQLBQLBQL
Brain (medulla)0.165BQLBQLBQL
Spinal cord0.139BQLBQLBQL
Cecum13.99.011.62BQL
Large intestine5.703.731.22BQL
Small intestine64.41.090.805BQL
Skeletal muscle3.750BQLBQLBQL
  • BQL, below quantitation limit (0.120 μg equivalent/g tissue).