Summary of kobs and the statistical tests for kobs[I] vs. kobs[0 μM]
A compound is declared to be TDI when at least one p < 0.05.
| Compound | Concentration | kobs (S.E.) | Significant TDI (p ≤ 0.05) |
|---|---|---|---|
| μM | (min−1) | ||
| Ketoconazole | 0 | 0.0053 (0.0012) | |
| 0.01 | 0.0057 (0.0017) | No (p = 0.8459) | |
| 0.04 | 0.0037 (0.0014) | No (p = 0.3782) | |
| 0.16 | 0.0021 (0.0016) | No (p = 0.1126) | |
| 0.63 | 0.0019 (0.0016) | No (p = 0.0774) | |
| 2.5 | 0.0002 (0.0024) | No (p = 0.0532) | |
| 10 | 0.0013 (0.0021) | No (p = 0.0890) | |
| Pioglitazone | 0 | 0.0022 (0.0008) | |
| 3 | 0.0021 (0.0012) | No (p = 0.9001) | |
| 6 | 0.0037 (0.0011) | No (p = 0.3080) | |
| 10 | 0.0044 (0.0008) | No (p = 0.0665) | |
| 30 | 0.0065 (0.0009) | Yes (p = 0.0007) | |
| 60 | 0.0123 (0.001) | Yes (p < 0.0001) | |
| 80 | 0.0161 (0.0016) | Yes (p < 0.0001) | |
| Rosiglitazone | 0 | 0.0043 (0.0009) | |
| 3 | 0.0077 (0.0006) | Yes (p = 0.0013) | |
| 6 | 0.0095 (0.0006) | Yes (p < 0.0001) | |
| 10 | 0.0110 (0.0005) | Yes (p < 0.0001) | |
| 30 | 0.0124 (0.0008) | Yes (p < 0.0001) | |
| 60 | 0.0136 (0.0005) | Yes (p < 0.0001) | |
| 80 | 0.0143 (0.0007) | Yes (p < 0.0001) | |
| Raloxifene | 0 | 0.0038 (0.0010) | |
| 1 | 0.0533 (0.0023) | Yes (p < 0.0001) | |
| 2 | 0.0760 (0.0024) | Yes (p < 0.0001) | |
| 4 | 0.1335 (0.0056) | Yes (p < 0.0001) | |
| 8 | 0.1866 (0.0135) | Yes (p < 0.0001) | |
| 15 | 0.2021 (0.0095) | Yes (p < 0.0001) | |
| 30 | 0.2004 (0.0041) | Yes (p < 0.0001) | |
| Erythromycin | 0 | 0.0032 (0.0011) | |
| 3 | 0.0100 (0.0012) | Yes (p < 0.0001) | |
| 6 | 0.0134 (0.0008) | Yes (p < 0.0001) | |
| 12.2 | 0.0173 (0.0011) | Yes (p < 0.0001) | |
| 24.6 | 0.0221 (0.0016) | Yes (p < 0.0001) | |
| 49.6 | 0.0273 (0.0012) | Yes (p < 0.0001) | |
| 100 | 0.0293 (0.0016) | Yes (p < 0.0001) |