TABLE 3

Repaglinide AUC increase produced by concomitant GEM administration at various timings/doses

Fold Change in Repaglinide AUC Produced by GEM
Report 1 (Backman et al., 2009)SimulatedReported
Dosing interval between GEM and repaglinide
 1 h6.497.56
 24 h1.782.86
 48 h1.251.42
 96 h1.050.98
Report 2 (Honkalammi et al., 2011)SimulatedReported
Dosing interval between GEM and repaglinide
 0 h4.854.98
 1 h6.496.36
 3 h5.226.59
 6 h3.935.43
Report 3 (Honkalammi et al., 2012)SimulatedReported
Dose of GEM
 30 mg3.353.40
 100 mg4.225.57
 600 mg6.497.04