TABLE 1

Human, rat, and dog biliary clearance

Values are presented in units of ml/min/kg as total (CLbile) and unbound (CLbile,u) after being adjusted for plasma protein binding.

Human CLbileHuman CLbile,uRat CLbileRat CLbile,uDog CLbileDog CLbile,u
Doxorubicin2.035a7.2683.68b10.821.720c5.059
Digoxin1.595d2.2793.03e4.3291.313f2.680
Erythromycin1.147g7.16917.4h22.382.376i4.483
Cefazolin0.001j0.0071.40k11.240.066l0.089
Cefamandole0.012m0.0485.00n29.41
Cephalexin0.0134o0.0161.07o1.408
Cefotetan0.048o0.3206.14o8.7710.696o1.141
Cefixime0.140p0.4521.00q7.143
Ceftriaxone0.070r0.9330.82s12.732.5s2.907
Cefpiramide0.040t1.0005.22u9.6670.979v1.399
Cefoperazone0.149w2.12916.3x22.03
Valsartan0.431y10.77512.5z378.8
Moxalactam0.003aa0.0082.19ab4.294
Methotrexate0.048o1.1089.60o12.470.217o0.344
Pravastatin3.105ac6.21027.5ad78.57
Diclofenac0.042ae8.4000.85af94.44
Ranitidine0.153ag0.1611.40o1.556
Vincristine0.209ah0.52333.1e84.87
Methadone0.001ai0.0065.22aj14.33
Fexofenadine1.400ak4.0008.00al42.11
Ciprofloxacin0.059am0.0843.50an6.140
Napsagatran4.357o7.92234.7o105.232.75o62.98
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