V_{max} | K_{m} | P_{app}_{(−P450)} | |
---|---|---|---|

pmol metabolite/min
per cm^{2} | μM | nm/sec | |

P-gp-competent | 31 ± 1 | 22 ± 4.8^{***} | 0.61 ± 0.047*** |

P-gp deficient | 30 ± 3.2 | 4.5 ± 2.4 | 5.5 ± 1.1 |

P-gp, P-glycoprotein.

↵***

*P*< 0.001 significance between P-gp-competent and P-gp-deficient mice, as determined using a two-tailed Wilcoxon*t*test.